Cyclophosphamide decreases the number, percentage and the function of CD25+ CD4+ regulatory T cells, which suppress induction of contact hypersensitivity
Y Ikezawa, M Nakazawa, C Tamura… - Journal of …, 2005 - Elsevier
BACKGROUND:: It is well known that cyclophosphamide (Cy) treatment before sensitization
paradoxically enhances rather than suppresses contact hypersensitivity (CH) reactions. In
fact, Cy-treated mice developed a significant (p< 0.05) increase of the CH reactions to 2, 4, 6-
trinitro-1-chrolobenzene (TNCB) in comparison with untreated mice. OBJECTIVE:: In order to
examine whether the target cells of Cy in the immuno-augmentative effect are CD25+ CD4+
regulatory T cells or not, we investigated effect of Cy treatment on CD25+ CD4+ T cells …
paradoxically enhances rather than suppresses contact hypersensitivity (CH) reactions. In
fact, Cy-treated mice developed a significant (p< 0.05) increase of the CH reactions to 2, 4, 6-
trinitro-1-chrolobenzene (TNCB) in comparison with untreated mice. OBJECTIVE:: In order to
examine whether the target cells of Cy in the immuno-augmentative effect are CD25+ CD4+
regulatory T cells or not, we investigated effect of Cy treatment on CD25+ CD4+ T cells …