[HTML][HTML] The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome
UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism,
Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked
UBE3A mutant (UBE3A T485A) that disrupts phosphorylation control of UBE3A activity.
Through quantitative proteomics and reporter assays, we found that the UBE3A T485A
protein ubiquitinates multiple proteasome subunits, reduces proteasome subunit abundance
and activity, stabilizes nuclear β-catenin, and stimulates canonical Wnt signaling more …
Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked
UBE3A mutant (UBE3A T485A) that disrupts phosphorylation control of UBE3A activity.
Through quantitative proteomics and reporter assays, we found that the UBE3A T485A
protein ubiquitinates multiple proteasome subunits, reduces proteasome subunit abundance
and activity, stabilizes nuclear β-catenin, and stimulates canonical Wnt signaling more …