Abnormal myelination in Angelman syndrome
I Harting, A Seitz, D Rating, K Sartor, J Zschocke… - european journal of …, 2009 - Elsevier
Patients with Angelman syndrome (OMIM# 105830) are generally thought to have normal
brain imaging studies except for occasional minor cerebral atrophy. We report 9 patients
with genetically proven Angelman syndrome, who were examined by magnetic resonance
imaging (MRI) between the ages of 7.5 months and 5 years. MRI in the 5 patients examined
during infancy revealed myelination delay and a deficit of white matter. Retarded and/or
abnormal myelination in Angelman syndrome seems to be a common finding that may be …
brain imaging studies except for occasional minor cerebral atrophy. We report 9 patients
with genetically proven Angelman syndrome, who were examined by magnetic resonance
imaging (MRI) between the ages of 7.5 months and 5 years. MRI in the 5 patients examined
during infancy revealed myelination delay and a deficit of white matter. Retarded and/or
abnormal myelination in Angelman syndrome seems to be a common finding that may be …
