The HumanE6-APGene (UBE3A) encodes three potential protein isoforms generated by differential splicing
Y Yamamoto, JM Huibregtse, PM Howley - Genomics, 1997 - Elsevier
Y Yamamoto, JM Huibregtse, PM Howley
Genomics, 1997•ElsevierTheE6-APgene (UBE3A) encodes an E3 ubiquitin–protein ligase that binds the human
papillomavirus E6 oncoprotein and catalyzes the ubiquitination of p53. Recent studies have
also established that mutations inE6-APare the genetic basis of the Angelman syndrome in
humans. In this study we present the genomic structure of the coding region ofE6-APand an
analysis of a set of fiveE6-APmRNAs with the potential to encode three protein isoforms of
the E6-AP protein (isoforms I, II, and III) that differ at their extreme amino-termini. These …
papillomavirus E6 oncoprotein and catalyzes the ubiquitination of p53. Recent studies have
also established that mutations inE6-APare the genetic basis of the Angelman syndrome in
humans. In this study we present the genomic structure of the coding region ofE6-APand an
analysis of a set of fiveE6-APmRNAs with the potential to encode three protein isoforms of
the E6-AP protein (isoforms I, II, and III) that differ at their extreme amino-termini. These …
TheE6-APgene (UBE3A) encodes an E3 ubiquitin–protein ligase that binds the human papillomavirus E6 oncoprotein and catalyzes the ubiquitination of p53. Recent studies have also established that mutations inE6-APare the genetic basis of the Angelman syndrome in humans. In this study we present the genomic structure of the coding region ofE6-APand an analysis of a set of fiveE6-APmRNAs with the potential to encode three protein isoforms of the E6-AP protein (isoforms I, II, and III) that differ at their extreme amino-termini. These transcripts were expressed in a variety of different cell lines examined.
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