Seizure treatment in Angelman syndrome: A case series from the Angelman Syndrome Clinic at Massachusetts General Hospital
Epilepsy is a common feature of Angelman syndrome (~ 80–90%), with the most common
seizure types including myoclonic, atonic, atypical absence, focal, and generalized tonic–
clonic. Seizure types are similar among the various genetic subtypes, but epilepsy in those
with maternal deletions is more frequent and more refractory to medication. Treatment with
older antiepileptic drugs such as valproic acid and clonazepam is effective, but these
medications tend to have less favorable side effect profiles in Angelman syndrome …
seizure types including myoclonic, atonic, atypical absence, focal, and generalized tonic–
clonic. Seizure types are similar among the various genetic subtypes, but epilepsy in those
with maternal deletions is more frequent and more refractory to medication. Treatment with
older antiepileptic drugs such as valproic acid and clonazepam is effective, but these
medications tend to have less favorable side effect profiles in Angelman syndrome …