[HTML][HTML] Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

J Berrios, AM Stamatakis, PA Kantak… - Nature …, 2016 - nature.com
J Berrios, AM Stamatakis, PA Kantak, ZA McElligott, MC Judson, M Aita, M Rougie…
Nature communications, 2016nature.com
Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area
projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal
terminals co-release other neurotransmitters including glutamate and GABA, whose roles in
regulating motivated behaviours are currently being investigated. Here we demonstrate that
loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons
impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking …
Abstract
Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are currently being investigated. Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.
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