The regulation of Sox9 expression in the gonad
N Gonen, R Lovell-Badge - Current topics in developmental biology, 2019 - Elsevier
The bipotential nature of cell types in the early developing gonad and the process of sex
determination leading to either testis or ovary differentiation makes this an interesting system
in which to study transcriptional regulation of gene expression and cell fate decisions. SOX9
is a transcription factor with multiple roles during development, including being a key player
in mediating testis differentiation and therefore subsequent male development. Loss of Sox9
expression in both humans and mice results in XY female development, whereas its …
determination leading to either testis or ovary differentiation makes this an interesting system
in which to study transcriptional regulation of gene expression and cell fate decisions. SOX9
is a transcription factor with multiple roles during development, including being a key player
in mediating testis differentiation and therefore subsequent male development. Loss of Sox9
expression in both humans and mice results in XY female development, whereas its …