Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney
K Kobayashi, S Uchida, S Mizutani… - Journal of the …, 2001 - journals.lww.com
Abstract CLC-K2, a kidney-specific member of the CLC chloride channel family, is thought to
play an important role in the transepithelial Cl-transport in the kidney. This consensus was
first reached shortly after it was demonstrated that the mutations of the human CLCNKB
gene resulted in Bartter's syndrome type III. To clarify the pathogenesis, the exact intrarenal
and cellular localization of CLC-K2 by immunohistochemistry of the Clcnk1-/-mouse kidney
were investigated by use of an anti-CLC-K antibody that recognized both CLC-K1 and CLC …
play an important role in the transepithelial Cl-transport in the kidney. This consensus was
first reached shortly after it was demonstrated that the mutations of the human CLCNKB
gene resulted in Bartter's syndrome type III. To clarify the pathogenesis, the exact intrarenal
and cellular localization of CLC-K2 by immunohistochemistry of the Clcnk1-/-mouse kidney
were investigated by use of an anti-CLC-K antibody that recognized both CLC-K1 and CLC …