[HTML][HTML] ADAMTS‐13, von Willebrand factor and related parameters in severe sepsis and septic shock

JAK Hovinga, S Zeerleder, P Kessler, TR De Wit… - Journal of Thrombosis …, 2007 - Elsevier
Background: Insufficient control of von Willebrand factor (VWF) multimer size as a result of
severely deficient ADAMTS‐13 activity results in thrombotic thrombocytopenic purpura
associated with microvascluar thrombosis and platelet consumption, features not seldom
seen in severe sepsis and septic shock. Methods: ADAMTS‐13 activity and VWF parameters
of 40 patients with severe sepsis or septic shock were compared with those of 40 healthy
controls of the same age and gender and correlated with clinical findings and sepsis …