Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2

CM Alberini, DY Chen - Trends in neurosciences, 2012 - cell.com
CM Alberini, DY Chen
Trends in neurosciences, 2012cell.com
Life and societies would change significantly if memory capacity or persistence in health and
disease could be enhanced. It has been known for many years that memory can be
improved and strengthened. Substances known to enhance memory include hormones,
neurotransmitters, neuropeptides and metabolic substrates. Recently, attention has been
given to identifying the molecular mechanisms and targets whereby memory enhancement
can be achieved. One approach would be to target the physiological changes that are …
Life and societies would change significantly if memory capacity or persistence in health and disease could be enhanced. It has been known for many years that memory can be improved and strengthened. Substances known to enhance memory include hormones, neurotransmitters, neuropeptides and metabolic substrates. Recently, attention has been given to identifying the molecular mechanisms and targets whereby memory enhancement can be achieved. One approach would be to target the physiological changes that are induced by learning and naturally required for memory strengthening via consolidation and reconsolidation. Here, we review approaches that boost memories by targeting the cAMP response element binding protein-CCAAT enhancer binding protein (CREB-C/EBP) pathway and/or its recently identified target gene insulin-like growth factor 2 (IGF2).
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