Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice
Background Identifying feasible therapeutic interventions is crucial for ameliorating the
intellectual disability and other afflictions of fragile X syndrome (FXS), the most common
inherited cause of intellectual disability and autism. Hippocampal glycogen synthase kinase-
3 (GSK3) is hyperactive in the mouse model of FXS (FX mice), and hyperactive GSK3
promotes locomotor hyperactivity and audiogenic seizure susceptibility in FX mice, raising
the possibility that specific GSK3 inhibitors may improve cognitive processes. Methods We …
intellectual disability and other afflictions of fragile X syndrome (FXS), the most common
inherited cause of intellectual disability and autism. Hippocampal glycogen synthase kinase-
3 (GSK3) is hyperactive in the mouse model of FXS (FX mice), and hyperactive GSK3
promotes locomotor hyperactivity and audiogenic seizure susceptibility in FX mice, raising
the possibility that specific GSK3 inhibitors may improve cognitive processes. Methods We …