There has been concern about possible long-term sequelae resembling myalgic
encephalomyelitis/chronic fatigue syndrome in COVID-19 patients. Clarifying the
mechanisms underlying such a “post-COVID-19 fatigue syndrome” is essential for the
development of preventive and early treatment methods for this syndrome. In the present
paper, by integrating insights pertaining to the glymphatic system and the nasal
cerebrospinal fluid outflow pathway with findings in patients with chronic fatigue syndrome …