HSD3B1 genotype and clinical outcomes in metastatic castration-sensitive prostate cancer
JWD Hearn, CJ Sweeney, N Almassi… - JAMA …, 2020 - jamanetwork.com
Importance The adrenal-restrictiveHSD3B1 (1245A) allele limits extragonadal
dihydrotestosterone synthesis, whereas the adrenal-permissiveHSD3B1 (1245C) allele
augments extragonadal dihydrotestosterone synthesis. Retrospective studies have
suggested an association between the adrenal-permissive allele, the frequency of which is
highest in white men, and early development of castration-resistant prostate cancer (CRPC).
Objective To examine the association between the adrenal-permissiveHSD3B1 (1245C) …
dihydrotestosterone synthesis, whereas the adrenal-permissiveHSD3B1 (1245C) allele
augments extragonadal dihydrotestosterone synthesis. Retrospective studies have
suggested an association between the adrenal-permissive allele, the frequency of which is
highest in white men, and early development of castration-resistant prostate cancer (CRPC).
Objective To examine the association between the adrenal-permissiveHSD3B1 (1245C) …