Abstract The CD200: CD200R1 inhibitory signaling pathway has been implicated in playing
a prominent role in limiting inflammation in a wide range of inflammatory diseases.
CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor
necrosis factor, interferons, and inducible nitric oxide synthase in response to selected
stimuli. Unsurprisingly, due to the regulatory role that CD200R1 plays in multiple
inflammatory pathways, an increasing number of parasitic, bacterial, and viral pathogens …