Nonclassical monocytes in health and disease
PB Narasimhan, P Marcovecchio… - Annual review of …, 2019 - annualreviews.org
Monocytes are innate blood cells that maintain vascular homeostasis and are early
responders to pathogens in acute infections. There are three well-characterized classes of
monocytes: classical (CD14+ CD16− in humans and Ly6Chi in mice), intermediate (CD14+
CD16+ in humans and Ly6C+ Treml4+ in mice), and nonclassical (CD14− CD16+ in
humans and Ly6Clo in mice). Classical monocytes are critical for the initial inflammatory
response. Classical monocytes can differentiate into macrophages in tissue and can …
responders to pathogens in acute infections. There are three well-characterized classes of
monocytes: classical (CD14+ CD16− in humans and Ly6Chi in mice), intermediate (CD14+
CD16+ in humans and Ly6C+ Treml4+ in mice), and nonclassical (CD14− CD16+ in
humans and Ly6Clo in mice). Classical monocytes are critical for the initial inflammatory
response. Classical monocytes can differentiate into macrophages in tissue and can …
