[HTML][HTML] Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is …
MC Wilson, D Meredith, JEM Fox, C Manoharan… - Journal of Biological …, 2005 - ASBMB
Translocation of monocarboxylate transporters MCT1 and MCT4 to the plasma membrane
requires CD147 (basigin) with which they remain tightly associated. However, the
importance of CD147 for MCT activity is unclear. MCT1 and MCT4 are both inhibited by the
cell-impermeant organomercurial reagent p-chloromercuribenzene sulfonate (pCMBS).
Here we demonstrate by site-directed mutagenesis that removal of all accessible cysteine
residues on MCT4 does not prevent this inhibition. pCMBS treatment of cells abolished co …
requires CD147 (basigin) with which they remain tightly associated. However, the
importance of CD147 for MCT activity is unclear. MCT1 and MCT4 are both inhibited by the
cell-impermeant organomercurial reagent p-chloromercuribenzene sulfonate (pCMBS).
Here we demonstrate by site-directed mutagenesis that removal of all accessible cysteine
residues on MCT4 does not prevent this inhibition. pCMBS treatment of cells abolished co …