The autophagy enhancer spermidine reverses arterial aging
TJ LaRocca, RA Gioscia-Ryan, CM Hearon Jr… - Mechanisms of ageing …, 2013 - Elsevier
Arterial aging, characterized by stiffening of large elastic arteries and the development of
arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the
hypothesis that spermidine, a nutrient associated with the anti-aging process autophagy,
would improve arterial aging. Aortic pulse wave velocity (aPWV), a measure of arterial
stiffness, was∼ 20% greater in old (O, 28 months) compared with young C57BL6 mice (Y, 4
months, P< 0.05). Arterial endothelium-dependent dilation (EDD), a measure of endothelial …
arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the
hypothesis that spermidine, a nutrient associated with the anti-aging process autophagy,
would improve arterial aging. Aortic pulse wave velocity (aPWV), a measure of arterial
stiffness, was∼ 20% greater in old (O, 28 months) compared with young C57BL6 mice (Y, 4
months, P< 0.05). Arterial endothelium-dependent dilation (EDD), a measure of endothelial …