[HTML][HTML] (D)-β-hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G

AKP Taggart, J Kero, X Gan, TQ Cai, K Cheng… - Journal of Biological …, 2005 - ASBMB
As a treatment for dyslipidemia, oral doses of 1–3 grams of nicotinic acid per day lower
serum triglycerides, raise high density lipoprotein cholesterol, and reduce mortality from
coronary heart disease (Tavintharan, S., and Kashyap, ML (2001) Curr. Atheroscler. Rep. 3,
74–82). These benefits likely result from the ability of nicotinic acid to inhibit lipolysis in
adipocytes and thereby reduce serum non-esterified fatty acid levels (Carlson, LA (1963)
Acta Med. Scand. 173, 719–722). In mice, nicotinic acid inhibits lipolysis via PUMA-G, a G i/o …