M1 means kill; M2 means heal
K Ley - The Journal of Immunology, 2017 - journals.aai.org
The Journal of Immunology, 2017•journals.aai.org
Macrophages are abundant in almost all tissues of all multicellular organisms, estimated to
total 10 10 cells in adult humans. Macrophage function is essential for health, as strikingly
demonstrated by the severe pathologies of macrophage-deficient animal models. Therefore,
understanding the activation and differentiation of macrophages is essential for
understanding immunology.In this Pillars of Immunology article, Charles Mills and
colleagues (1) first identified the fundamental M1/M2 polarization axis of macrophages …
total 10 10 cells in adult humans. Macrophage function is essential for health, as strikingly
demonstrated by the severe pathologies of macrophage-deficient animal models. Therefore,
understanding the activation and differentiation of macrophages is essential for
understanding immunology.In this Pillars of Immunology article, Charles Mills and
colleagues (1) first identified the fundamental M1/M2 polarization axis of macrophages …
Macrophages are abundant in almost all tissues of all multicellular organisms, estimated to total 10 10 cells in adult humans. Macrophage function is essential for health, as strikingly demonstrated by the severe pathologies of macrophage-deficient animal models. Therefore, understanding the activation and differentiation of macrophages is essential for understanding immunology.
In this Pillars of Immunology article, Charles Mills and colleagues (1) first identified the fundamental M1/M2 polarization axis of macrophages. Mills, who died on May 28, 2017, identified the most important dichotomy in macrophage function: he observed that M1 macrophages kill (infectious organisms, virus-infected cells, or tumor cells) and M2 macrophages heal (sterile wounds and, with less success, cancer).
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