[HTML][HTML] Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

ME Ertunc, GS Hotamisligil - Journal of lipid research, 2016 - ASBMB
Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids,
and triglycerides. These molecules represent a highly efficient energy resource and can act
as structural elements of membranes or as signaling molecules that regulate metabolic
homeostasis through many mechanisms. Cells possess an integrated set of response
systems to adapt to stresses such as those imposed by nutrient fluctuations during feeding-
fasting cycles. While lipids are pivotal for these homeostatic processes, they can also …