The immune system's involvement in obesity-driven type 2 diabetes
CJ Shu, C Benoist, D Mathis - Seminars in immunology, 2012 - Elsevier
CJ Shu, C Benoist, D Mathis
Seminars in immunology, 2012•ElsevierType 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated
incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the
decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the
cross-talk between the immune system and organismal metabolism. This review discusses
the connection between inflammation in adipose tissue and systemic insulin resistance,
focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this …
incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the
decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the
cross-talk between the immune system and organismal metabolism. This review discusses
the connection between inflammation in adipose tissue and systemic insulin resistance,
focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this …
Type 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the cross-talk between the immune system and organismal metabolism. This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease.
Elsevier