Preimplantation factor negates embryo toxicity and promotes embryo development in culture
CW Stamatkin, RG Roussev, M Stout… - Reproductive …, 2011 - Elsevier
Preimplantation factor (PIF) is secreted by viable mammalian embryos and promotes
implantation and trophoblast invasion. Whether PIF also has a direct protective or promoting
effect on the developing embryo in culture is unknown. This study examined the protective
effects of synthetic PIF (sPIF) on embryos cultured with embryo toxic serum (ETS) from
recurrent pregnancy loss patients (n= 14), by morphological criteria at 72h of culture, and
determined sPIF-promoting effect on singly cultured bovine IVF embryo development. sPIF …
implantation and trophoblast invasion. Whether PIF also has a direct protective or promoting
effect on the developing embryo in culture is unknown. This study examined the protective
effects of synthetic PIF (sPIF) on embryos cultured with embryo toxic serum (ETS) from
recurrent pregnancy loss patients (n= 14), by morphological criteria at 72h of culture, and
determined sPIF-promoting effect on singly cultured bovine IVF embryo development. sPIF …
