Fatty acid-binding protein 4 in cardiovascular and metabolic diseases

M Furuhashi - Journal of atherosclerosis and thrombosis, 2019 - jstage.jst.go.jp
M Furuhashi
Journal of atherosclerosis and thrombosis, 2019jstage.jst.go.jp
Fatty acid trafficking in cells affects many aspects of cellular function3). Fatty acids act both
as an energy source and as signals for metabolic regulations including gene expression,
inflammatory and metabolic responses, and growth and survival pathways. Fatty acid-
binding proteins (FABPs), a family of intracellular lipid chaperones, regulate lipid trafficking
and responses in cells and are linked to metabolic and inflammatory pathways3-6). FABPs
are abundantly expressed 14-15-kDa proteins that reversibly bind hydrophobic ligands …
Fatty acid trafficking in cells affects many aspects of cellular function3). Fatty acids act both as an energy source and as signals for metabolic regulations including gene expression, inflammatory and metabolic responses, and growth and survival pathways. Fatty acid-binding proteins (FABPs), a family of intracellular lipid chaperones, regulate lipid trafficking and responses in cells and are linked to metabolic and inflammatory pathways3-6). FABPs are abundantly expressed 14-15-kDa proteins that reversibly bind hydrophobic ligands, such as long-chain fatty acids and other lipids. It has been proposed that FABPs actively facilitate the transport of fatty acids to specific organelles in the cell for lipid oxidation in the mitochondrion or peroxisome, transcriptional regulation in the nucleus, signaling, trafficking and membrane synthesis in the endoplasmic reticulum (ER), and regula-
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