Glucose homeostasis in the newborn
R Hume, A Burchell, FLR Williams, DKM Koh - Early human development, 2005 - Elsevier
Hepatic glucose production by glycogenolysis and gluconeogenesis is essential to maintain
blood glucose levels, and the glucose-6-phosphatase system catalyses the terminal step of
both pathways. Developmental delays in the postnatal up-regulation of hepatic glucose-6-
phosphatase enzyme activity are common in preterm infants. Two groups of infants have
been identified with failure of developmental regulation of glucose homeostasis. Firstly, up to
20% of preterm infants about to be discharged home are at risk of hypoglycaemia if a feed is …
blood glucose levels, and the glucose-6-phosphatase system catalyses the terminal step of
both pathways. Developmental delays in the postnatal up-regulation of hepatic glucose-6-
phosphatase enzyme activity are common in preterm infants. Two groups of infants have
been identified with failure of developmental regulation of glucose homeostasis. Firstly, up to
20% of preterm infants about to be discharged home are at risk of hypoglycaemia if a feed is …