The skin is the primary barrier from the outside environment, protecting the host from injury,
infectious pathogens, water loss and solar ultraviolet radiation. In this role, it is supported by
a highly organized system comprising elements of innate and adaptive immunity, responsive
to inflammatory stimuli. The cutaneous immune system is regulated by mediators such as
cytokines and bioactive lipids that can initiate rapid immune responses with controlled
inflammation, followed by efficient resolution. However, when immune responses are …