CARD14-associated papulosquamous eruption: a spectrum including features of psoriasis and pityriasis rubra pilaris
BG Craiglow, LM Boyden, R Hu, M Virtanen… - Journal of the American …, 2018 - Elsevier
Background Heterozygous mutations in caspase recruitment domain family member 14
gene (CARD14) have been shown to be associated with psoriasis and familial pityriasis
rubra pilaris (PRP). Many subjects with CARD14 mutations display features of both
disorders, which can result in diagnostic uncertainty. In addition, these eruptions are often
recalcitrant to conventional psoriasis therapies such as methotrexate, oral retinoids, and
tumor necrosis factor-α inhibitors. Objective We sought to describe the clinical …
gene (CARD14) have been shown to be associated with psoriasis and familial pityriasis
rubra pilaris (PRP). Many subjects with CARD14 mutations display features of both
disorders, which can result in diagnostic uncertainty. In addition, these eruptions are often
recalcitrant to conventional psoriasis therapies such as methotrexate, oral retinoids, and
tumor necrosis factor-α inhibitors. Objective We sought to describe the clinical …