Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts

S van den Driesche, C McKinnell… - Environmental …, 2015 - ehp.niehs.nih.gov
Background Phthalate exposure induces germ cell effects in the fetal rat testis. Although
experimental models have shown that the human fetal testis is insensitive to the
steroidogenic effects of phthalates, the effects on germ cells have been less explored.
Objectives We sought to identify the effects of phthalate exposure on human fetal germ cells
in a dynamic model and to establish whether the rat is an appropriate model for investigating
such effects. Methods We used immunohistochemistry, immunofluorescence, and …