[HTML][HTML] Phosphorylation of p300 at serine 89 by protein kinase C
LW Yuan, JE Gambee - Journal of Biological Chemistry, 2000 - ASBMB
CREB-binding protein (CBP)/p300 plays an important role in the connection of many
different signal transduction pathways and the promotion of certain differentiation and
proliferation processes. This role depends upon the ability of CBP/p300 to serve as
coactivator for transcription factors. It has been suggested that CBP/p300 is regulated by
phosphorylation, but the nature of the phosphorylation, the responsible kinase in vivo, and
its physiological significance are still unclear. Here, we demonstrate the first identification of …
different signal transduction pathways and the promotion of certain differentiation and
proliferation processes. This role depends upon the ability of CBP/p300 to serve as
coactivator for transcription factors. It has been suggested that CBP/p300 is regulated by
phosphorylation, but the nature of the phosphorylation, the responsible kinase in vivo, and
its physiological significance are still unclear. Here, we demonstrate the first identification of …