KEPI, a PKC-dependent Protein Phosphatase 1 Inhibitor Regulated by Morphine∗
QR Liu, PW Zhang, Q Zhen, D Walther, XB Wang… - Journal of Biological …, 2002 - jbc.org
cDNAs encoding KEPI, a novel protein kinase C (PKC)-potentiated inhibitory protein for type
1 Ser/Thr protein phosphatase (PP1), were identified. They were found among morphine-
regulated brain mRNAs identified using subtracted differential display techniques. Full-
length rat, mouse, and human cDNA and genomic sequences were elucidated with library
screening and data base searching. Rat, mouse, and human KEPI cDNAs encode 164–165
amino acid proteins with calculated isoelectric points of 5.2. Each species' amino acid …
1 Ser/Thr protein phosphatase (PP1), were identified. They were found among morphine-
regulated brain mRNAs identified using subtracted differential display techniques. Full-
length rat, mouse, and human cDNA and genomic sequences were elucidated with library
screening and data base searching. Rat, mouse, and human KEPI cDNAs encode 164–165
amino acid proteins with calculated isoelectric points of 5.2. Each species' amino acid …
