Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor
Previous studies have shown that FKHR, a member of the forkhead family of transcription
factors, acts as a DNA binding-independent cofactor of nuclear receptors, including
estrogen, retinoid, and thyroid hormone receptors, in addition to the original function as a
DNA binding transcription factor that redistributes from the nucleus to the cytoplasm by
insulin-induced phosphorylation. Here, we demonstrated the physical interaction of FKHR
with hepatocyte nuclear factor (HNF)-4, a member of steroid/thyroid nuclear receptor …
factors, acts as a DNA binding-independent cofactor of nuclear receptors, including
estrogen, retinoid, and thyroid hormone receptors, in addition to the original function as a
DNA binding transcription factor that redistributes from the nucleus to the cytoplasm by
insulin-induced phosphorylation. Here, we demonstrated the physical interaction of FKHR
with hepatocyte nuclear factor (HNF)-4, a member of steroid/thyroid nuclear receptor …
