Protein Kinase C βII Regulates Akt Phosphorylation on Ser-473 in a Cell Type-and Stimulus-specific Fashion*♦
Y Kawakami, H Nishimoto, J Kitaura… - Journal of Biological …, 2004 - jbc.org
Akt (= protein kinase B), a subfamily of the AGC serine/threonine kinases, plays critical roles
in survival, proliferation, glucose metabolism, and other cellular functions. Akt activation
requires the recruitment of the enzyme to the plasma membrane by interacting with
membrane-bound lipid products of phosphatidylinositol 3-kinase. Membrane-bound Akt is
then phosphorylated at two sites for its full activation; Thr-308 in the activation loop of the
kinase domain is phosphorylated by 3-phosphoinositide-dependent kinase-1 (PDK1) and …
in survival, proliferation, glucose metabolism, and other cellular functions. Akt activation
requires the recruitment of the enzyme to the plasma membrane by interacting with
membrane-bound lipid products of phosphatidylinositol 3-kinase. Membrane-bound Akt is
then phosphorylated at two sites for its full activation; Thr-308 in the activation loop of the
kinase domain is phosphorylated by 3-phosphoinositide-dependent kinase-1 (PDK1) and …
