Metabolic syndrome is common in the general population, but there is little information
available on the underlying signaling mechanisms regulating triglyceride (TG) content in the
body. In the current study, we have uncovered a role for protein kinase Cβ (PKCβ) in TG
homeostasis by studying the consequences of a targeted disruption of this kinase. PKCβ-/-
mutant mice were considerably leaner and the size of white fat depots was markedly
decreased compared with wild-type littermates. TG content in the liver and skeletal muscle of …