[HTML][HTML] The ENCODE blacklist: identification of problematic regions of the genome
Functional genomics assays based on high-throughput sequencing greatly expand our
ability to understand the genome. Here, we define the ENCODE blacklist-a comprehensive
set of regions in the human, mouse, worm, and fly genomes that have anomalous,
unstructured, or high signal in next-generation sequencing experiments independent of cell
line or experiment. The removal of the ENCODE blacklist is an essential quality measure
when analyzing functional genomics data.
ability to understand the genome. Here, we define the ENCODE blacklist-a comprehensive
set of regions in the human, mouse, worm, and fly genomes that have anomalous,
unstructured, or high signal in next-generation sequencing experiments independent of cell
line or experiment. The removal of the ENCODE blacklist is an essential quality measure
when analyzing functional genomics data.
Abstract
Functional genomics assays based on high-throughput sequencing greatly expand our ability to understand the genome. Here, we define the ENCODE blacklist- a comprehensive set of regions in the human, mouse, worm, and fly genomes that have anomalous, unstructured, or high signal in next-generation sequencing experiments independent of cell line or experiment. The removal of the ENCODE blacklist is an essential quality measure when analyzing functional genomics data.
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