Focal adhesion signaling in heart failure
AM Samarel - Pflügers Archiv-European Journal of Physiology, 2014 - Springer
Pflügers Archiv-European Journal of Physiology, 2014•Springer
In this brief review, recent evidence is presented to indicate a role for specific components of
the cardiomyocyte costamere (and its related structure the focal adhesion complex of
cultured cardiomyocytes) in initiating and sustaining the aberrant signal transduction that
contributes to myocardial remodeling and the progression to heart failure (HF). Special
attention is devoted to the focal adhesion kinase family of nonreceptor protein tyrosine
kinases in bidirectional signal transduction during cardiac remodeling and HF progression …
the cardiomyocyte costamere (and its related structure the focal adhesion complex of
cultured cardiomyocytes) in initiating and sustaining the aberrant signal transduction that
contributes to myocardial remodeling and the progression to heart failure (HF). Special
attention is devoted to the focal adhesion kinase family of nonreceptor protein tyrosine
kinases in bidirectional signal transduction during cardiac remodeling and HF progression …
Abstract
In this brief review, recent evidence is presented to indicate a role for specific components of the cardiomyocyte costamere (and its related structure the focal adhesion complex of cultured cardiomyocytes) in initiating and sustaining the aberrant signal transduction that contributes to myocardial remodeling and the progression to heart failure (HF). Special attention is devoted to the focal adhesion kinase family of nonreceptor protein tyrosine kinases in bidirectional signal transduction during cardiac remodeling and HF progression. Finally, some speculations and directions for future study are provided for this rapidly developing field of research.
Springer