Serum midkine as a predictor of cardiac events in patients with chronic heart failure
T Kitahara, T Shishido, S Suzuki, S Katoh… - Journal of cardiac …, 2010 - Elsevier
BACKGROUND: Midkine, a heparin-binding growth factor, has various functions such as
migration of inflammatory cell and anti-apoptotic effect. Invasion of inflammatory cell and
cardiomyocyte apoptosis are involved in development and progression of heart failure (HF).
However, the relationship between midkine and HF has not been previously examined.
Therefore, we examined clinical significance of serum midkine levels to determine the
prognosis of HF patients. METHODS AND RESULTS: Serum levels of midkine were …
migration of inflammatory cell and anti-apoptotic effect. Invasion of inflammatory cell and
cardiomyocyte apoptosis are involved in development and progression of heart failure (HF).
However, the relationship between midkine and HF has not been previously examined.
Therefore, we examined clinical significance of serum midkine levels to determine the
prognosis of HF patients. METHODS AND RESULTS: Serum levels of midkine were …