Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts
D Filipp, B Moemeni, A Ferzoco… - Journal of Biological …, 2008 - jbc.org
Mechanisms regulating the activation and delivery of function of Lck and Fyn are central to
the generation of the most proximal signaling events emanating from the T cell antigen
receptor (TcR) complex. Recent results demonstrate that lipid rafts (LR) segregate Lck and
Fyn and play a fundamental role in the temporal and spatial coordination of their activation.
Specifically, TcR-CD4 co-aggregation-induced Lck activation outside LR results in Lck
translocation to LR where the activation of LR-resident Fyn ensues. Here we report a …
the generation of the most proximal signaling events emanating from the T cell antigen
receptor (TcR) complex. Recent results demonstrate that lipid rafts (LR) segregate Lck and
Fyn and play a fundamental role in the temporal and spatial coordination of their activation.
Specifically, TcR-CD4 co-aggregation-induced Lck activation outside LR results in Lck
translocation to LR where the activation of LR-resident Fyn ensues. Here we report a …
