Recent investigations have focused on characterizing the molecular components of the
podocyte intercellular junction, because several of these components, including Nephrin,
are functionally necessary for development of normal podocyte structure and filter integrity.
Accumulating evidence suggests that the Nephrin-associated protein complex is a signaling
nexus. As such, Nephrin-dependent signaling might be mediated in part through Nephrin
phosphorylation. Described are biochemical and mouse genetics experiments …