NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases
P Gerke, L Sellin, O Kretz, D Petraschka… - Journal of the …, 2005 - journals.lww.com
The NEPH family comprises three transmembrane proteins of the Ig superfamily interacting
with the glomerular slit diaphragm proteins podocin and ZO-1. NEPH1 binds to nephrin,
another component of the slit diaphragm, and loss of either partner causes heavy
proteinuria. NEPH2, which is strongly conserved among a large number of species, is also
expressed in the kidney; however, its function is unknown. The authors raised NEPH2
antisera to demonstrate NEPH2 expression in a variety of mouse tissues, including the …
with the glomerular slit diaphragm proteins podocin and ZO-1. NEPH1 binds to nephrin,
another component of the slit diaphragm, and loss of either partner causes heavy
proteinuria. NEPH2, which is strongly conserved among a large number of species, is also
expressed in the kidney; however, its function is unknown. The authors raised NEPH2
antisera to demonstrate NEPH2 expression in a variety of mouse tissues, including the …