CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont
N Shulzhenko, X Dong, D Vyshenska, RL Greer… - Clinical …, 2018 - Elsevier
Common variable immunodeficiency (CVID), the most common symptomatic primary
antibody deficiency, is accompanied in some patients by a duodenal inflammation and
malabsorption syndrome known as CVID enteropathy (E-CVID). The goal of this study was
to investigate the immunological abnormalities in CVID patients that lead to enteropathy as
well as the contribution of intestinal microbiota to this process. We found that, in contrast to
noE-CVID patients (without enteropathy), E-CVID patients have exceedingly low levels of …
antibody deficiency, is accompanied in some patients by a duodenal inflammation and
malabsorption syndrome known as CVID enteropathy (E-CVID). The goal of this study was
to investigate the immunological abnormalities in CVID patients that lead to enteropathy as
well as the contribution of intestinal microbiota to this process. We found that, in contrast to
noE-CVID patients (without enteropathy), E-CVID patients have exceedingly low levels of …
