Immune competence and switched memory B cells in common variable immunodeficiency
J Ko, L Radigan, C Cunningham-Rundles - Clinical Immunology, 2005 - Elsevier
Common variable immunodeficiency (CVID) is presumed to be a heterogenous group of
disorders with potentially separate etiologies. Memory B cell subsets, characterized by
CD27 expression, have been suggested as a means to subclassify CVID patients. 53
patients were subdivided based on percentages of switched memory B cells (CD27+ IgM−
IgD−): 33 were placed in Group I (< 0.4% CD27+ IgM− IgD− cells/peripheral lymphocytes)
and 20 in Group II (> 0.4%). The median serum IgG for subjects in Group I was lower at 145 …
disorders with potentially separate etiologies. Memory B cell subsets, characterized by
CD27 expression, have been suggested as a means to subclassify CVID patients. 53
patients were subdivided based on percentages of switched memory B cells (CD27+ IgM−
IgD−): 33 were placed in Group I (< 0.4% CD27+ IgM− IgD− cells/peripheral lymphocytes)
and 20 in Group II (> 0.4%). The median serum IgG for subjects in Group I was lower at 145 …