Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development
M Dzidic, TR Abrahamsson, A Artacho… - Journal of Allergy and …, 2017 - Elsevier
Background Although a reduced gut microbiota diversity and low mucosal total IgA levels in
infancy have been associated with allergy development, IgA responses to the gut microbiota
have not yet been studied. Objective We sought to determine the proportions of IgA coating
together with the characterization of the dominant bacteria, bound to IgA or not, in infant
stool samples in relation to allergy development. Methods A combination of flow cytometric
cell sorting and deep sequencing of the 16S rDNA gene was used to characterize the …
infancy have been associated with allergy development, IgA responses to the gut microbiota
have not yet been studied. Objective We sought to determine the proportions of IgA coating
together with the characterization of the dominant bacteria, bound to IgA or not, in infant
stool samples in relation to allergy development. Methods A combination of flow cytometric
cell sorting and deep sequencing of the 16S rDNA gene was used to characterize the …