Synergistic convergence of microbiota-specific systemic IgG and secretory IgA
J Fadlallah, D Sterlin, C Fieschi, C Parizot… - Journal of Allergy and …, 2019 - Elsevier
Background Commensals induce local IgA responses essential to the induction of tolerance
to gut microbiota, but it remains unclear whether antimicrobiota responses remain confined
to the gut. Objective The aim of this study was to investigate systemic and intestinal
responses against the whole microbiota under homeostatic conditions and in the absence of
IgA. Methods We analyzed blood and feces from healthy donors, patients with selective IgA
deficiency (SIgAd), and patients with common variable immunodeficiency (CVID) …
to gut microbiota, but it remains unclear whether antimicrobiota responses remain confined
to the gut. Objective The aim of this study was to investigate systemic and intestinal
responses against the whole microbiota under homeostatic conditions and in the absence of
IgA. Methods We analyzed blood and feces from healthy donors, patients with selective IgA
deficiency (SIgAd), and patients with common variable immunodeficiency (CVID) …