Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency
M Cols, A Rahman, PJ Maglione… - Journal of Allergy and …, 2016 - Elsevier
Background Common variable immunodeficiency (CVID) is an antibody deficiency treated
with immunoglobulin; however, patients can have noninfectious inflammatory conditions that
lead to heightened morbidity and mortality. Objectives Modular analyses of RNA transcripts
in whole blood previously identified an upregulation of many interferon-responsive genes. In
this study we sought the cell populations leading to this signature. Methods Lymphoid cells
were measured in peripheral blood of 55 patients with CVID (31 with and 24 without …
with immunoglobulin; however, patients can have noninfectious inflammatory conditions that
lead to heightened morbidity and mortality. Objectives Modular analyses of RNA transcripts
in whole blood previously identified an upregulation of many interferon-responsive genes. In
this study we sought the cell populations leading to this signature. Methods Lymphoid cells
were measured in peripheral blood of 55 patients with CVID (31 with and 24 without …