Background & Aims Liver graft injury and tumor recurrence are the major challenges of liver
transplantation for the patients with hepatocellular carcinoma (HCC). Here, we aimed to
explore the role and mechanism of liver graft injury mobilizing regulatory T cells (Tregs),
which lead to late phase tumor recurrence after liver transplantation. Methods The
correlation among tumor recurrence, liver graft injury and Tregs mobilization were studied in
257 liver transplant recipients with HCC and orthotopic rat liver transplantation models. The …