IL-12Rβ2 has a protective role in relapsing–remitting experimental autoimmune encephalomyelitis
C Xie, B Ciric, S Yu, GX Zhang, A Rostami - Journal of neuroimmunology, 2016 - Elsevier
IL-12Rβ2 is a common receptor subunit of heterodimeric receptors for IL-12 and IL-35, two
cytokines that are implicated in immunopathogenesis of experimental autoimmune
encephalomyelitis (EAE), an animal model of multiple sclerosis. We evaluated the role of IL-
12Rβ2 in relapsing–remitting EAE (RR-EAE). IL-12Rβ2-deficient SJL/J mice developed
markedly more severe clinical EAE, and had greater mortality and more severe relapses
compared with wild-type controls. IL-12Rβ2-deficient EAE mice also had more infiltrating …
cytokines that are implicated in immunopathogenesis of experimental autoimmune
encephalomyelitis (EAE), an animal model of multiple sclerosis. We evaluated the role of IL-
12Rβ2 in relapsing–remitting EAE (RR-EAE). IL-12Rβ2-deficient SJL/J mice developed
markedly more severe clinical EAE, and had greater mortality and more severe relapses
compared with wild-type controls. IL-12Rβ2-deficient EAE mice also had more infiltrating …