Expression of TCTP antisense in CD25high regulatory T cells aggravates cuff-injured vascular inflammation
Z Xiong, Y Yan, J Song, P Fang, Y Yin, Y Yang… - Atherosclerosis, 2009 - Elsevier
This study examines our hypothesis that translationally controlled tumor protein (TCTP)
expression in CD4+ CD25high regulatory T cells (Tregs) is critical for the interleukin-2 (IL-2)
withdrawal-triggered apoptosis pathway in Tregs, and modulation of Treg apoptosis
pathway affects development of vascular inflammation. To test this hypothesis, we
established a Tregs-specific TCTP antisense transgenic mouse model. Lower TCTP
expression in Tregs than in CD4+ CD25− T cells is associated with the higher susceptibility …
expression in CD4+ CD25high regulatory T cells (Tregs) is critical for the interleukin-2 (IL-2)
withdrawal-triggered apoptosis pathway in Tregs, and modulation of Treg apoptosis
pathway affects development of vascular inflammation. To test this hypothesis, we
established a Tregs-specific TCTP antisense transgenic mouse model. Lower TCTP
expression in Tregs than in CD4+ CD25− T cells is associated with the higher susceptibility …
