The forkhead transcription factors play important roles in vascular pathology and immunology
XF Yang, P Fang, S Meng, M Jan, X Xiong… - … Factors: Vital Elements …, 2010 - Springer
Forkhead Transcription Factors: Vital Elements in Biology and Medicine, 2010•Springer
Transcription factor families are a small number of upstream master genes in “higher
hierarchy” that control the expression of a large number of downstream genes. These
transcription factors have been found to integrate the signaling pathways underlying the
pathogenesis of cardiovascular diseases with or without autoimmune inflammatory
mechanisms. In this chapter, we organize our analysis of recent progress in characterization
of forkhead (FOX) transcription factor family members in vascular pathology and immune …
hierarchy” that control the expression of a large number of downstream genes. These
transcription factors have been found to integrate the signaling pathways underlying the
pathogenesis of cardiovascular diseases with or without autoimmune inflammatory
mechanisms. In this chapter, we organize our analysis of recent progress in characterization
of forkhead (FOX) transcription factor family members in vascular pathology and immune …
Abstract
Transcription factor families are a small number of upstream master genes in “higher hierarchy” that control the expression of a large number of downstream genes. These transcription factors have been found to integrate the signaling pathways underlying the pathogenesis of cardiovascular diseases with or without autoimmune inflammatory mechanisms. In this chapter, we organize our analysis of recent progress in characterization of forkhead (FOX) transcription factor family members in vascular pathology and immune regulation into the following sections: (1) Introduction of the FOX transcription factor superfamily; (2) FOX transcription factors and endothelial cell pathology; (3) FOX transcription factors and vascular smooth muscle cells; and (4) FOX transcription factors, inflammation and immune system. Advances in these areas suggest that the FOX transcription factor family is important in regulating vascular development and the pathogenesis of autoimmune inflammatory cardiovascular diseases.
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