IgA nephropathy: molecular mechanisms of the disease
J Mestecky, M Raska, BA Julian… - Annual Review of …, 2013 - annualreviews.org
Studies of molecular and cellular interactions involved in the pathogenesis of IgA
nephropathy have revealed the autoimmune nature of this most common primary
glomerulonephritis. In patients with this disease, altered glycan structures in the unique
hinge region of the heavy chains of IgA1 molecules lead to the exposure of antigenic
determinants, which are recognized by naturally occurring antiglycan antibodies of the IgG
and/or IgA1 isotype. As a result, nephritogenic immune complexes form in the circulation …
nephropathy have revealed the autoimmune nature of this most common primary
glomerulonephritis. In patients with this disease, altered glycan structures in the unique
hinge region of the heavy chains of IgA1 molecules lead to the exposure of antigenic
determinants, which are recognized by naturally occurring antiglycan antibodies of the IgG
and/or IgA1 isotype. As a result, nephritogenic immune complexes form in the circulation …
