[HTML][HTML] Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive …

FA De La Peņa, K Kanasaki, M Kanasaki… - Journal of Biological …, 2011 - ASBMB
Activation of oncogenes or inactivation of tumor suppressors in urothelium is considered
critical for development of urothelial cancer. Here we report cloning of the urothelium-
specific promoter uroplakin-II (UPK II) and generation of transgenic mice in which
expression of SV40 large T antigen is driven by UPK II promoter. Inactivation of tumor
suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carcinoma,
resembling human high-grade carcinoma in situ. Specific deletion of p53 in urothelial cells …