Altered dendritic cell function in normal pregnancy
V Bachy, DJ Williams, MAA Ibrahim - Journal of reproductive immunology, 2008 - Elsevier
In pregnancy, maternal immunity is skewed to favour maintenance of gestation and immune
tolerance of a semi-allogeneic fetus. Dendritic cells are thought to play a crucial role in
mediating the balance between immunity and tolerance, and determining the type of T
helper cell response. We postulated that myeloid dendritic cells would be modified in
pregnancy to favour type 2 T helper cell responses. We show that the proportion of
circulating myeloid dendritic cells expressing CD86 and staining for HLA-DR were …
tolerance of a semi-allogeneic fetus. Dendritic cells are thought to play a crucial role in
mediating the balance between immunity and tolerance, and determining the type of T
helper cell response. We postulated that myeloid dendritic cells would be modified in
pregnancy to favour type 2 T helper cell responses. We show that the proportion of
circulating myeloid dendritic cells expressing CD86 and staining for HLA-DR were …
